Name Wimolpak Sriwai,PhD
ตำแหน่ง
ตำแหน่งทางวิชาการ อาจารย์
Phone number
0-2986-9213-9 ต่อ
Email address swimol@yahoo.com
     
ผลงานวิจัย (12 เรื่อง)
1.Huang J, Zhou H, Mahavadi S, Sriwai W, Lyall V, Murthy KS. Signaling pathways mediating gastrointestinal smooth muscle contraction and MLC20 phosphorylation by motilin receptors. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G23-31.
2.Huang J, Mahavadi S, Sriwai W, Hu W, Murthy KS. Gi-coupled receptors mediate phosphorylation of CPI-17 and MLC20 via preferential activation of the PI3K/ILK pathway. Biochem J. 2006 May 15;396(1):193-200.
3.Huang J, Zhou H, Mahavadi S, Sriwai W, Murthy KS. Inhibition of Gαq-dependent PLC-β1 activity by PKG and PKA is mediated by phosphorylation of RGS4 and GRK2. Am J Physiol Cell Physiol. 2007 Jan;292(1):C200-8. Epub 2006 Aug 2.
4.Mahavadi S, Huang J, Sriwai W, Rao KR, Murthy KS. Cross-regulation of VPAC2 receptor internalization by m2 receptors via c-Src-mediated phosphorylation of GRK2. Regul Pept. 2007 Mar 1;139(1-3):109-14.
5.Huang J, Mahavadi S, Sriwai W, Grider JR, Murthy KS. Cross-regulation of VPAC(2) receptor desensitization by M(3) receptors via PKC-mediated phosphorylation of RKIP and inhibition of GRK2. Am J Physiol Gastrointest Liver Physiol. 2007 Mar;292(3):G867-74.
6.Murthy KS and Sriwai W. Stimulatory phosphorylation of cAMP-specific PDE4D5 by contractile agonists is mediated by PKC-dependent inactivation of protein phosphatase 2A. Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G327-35.
7.Murthy KS, Mahavadi S, Huang J, Zhou H, Sriwai W. Phosphorylation of GRK2 by PKA augments GRK2-mediated phosphorylation, internalization, and desensitization of VPAC2 receptors in smooth muscle. Am J Physiol Cell Physiol. 2008 Feb;294(2):C477-87.
8.Sriwai W, Zhou H, Murthy KS. G(q)-dependent signalling by the lysophosphatidic acid receptor LPA(3) in gastric smooth muscle: reciprocal regulation of MYPT1 phosphorylation by Rho kinase and cAMP-independent PKA. Biochem J. 2008 May 1;411(3):543-51.
9.Jk(a-b-) phenotype screening by the urea lysis test in Thai blood donors. Deelert S, Thippayaboon P, Sriwai W, Sriwanitchrak P, Tubrod J, Kupatawintu P, Nathalang O. Blood Transfus. 2010 Jan;8(1):17-20
10.Inhibitory signaling by CB1 receptors in smooth muscle mediated by GRK5/β-arrestin activation of ERK1/2 and Src kinase. Mahavadi S, Sriwai W, Huang J, Grider JR, Murthy KS. Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G535-45.
11.Distinctive G Protein-Dependent Signaling by Protease-Activated Receptor 2 (PAR2) in Smooth Muscle: Feedback Inhibition of RhoA by cAMP-Independent PKA. Sriwai W, Mahavadi S, Al-Shboul O, Grider JR, Murthy KS. PLoS One. 2013 Jun 18;8(6):e66743. Print 2013.
12.Differential expression of multidrug resistance protein 5 and phosphodiesterase 5 and regulation of cGMP levels in phasic and tonic smooth muscle. Al-Shboul O, Mahavadi S, Sriwai W, Grider JR, Murthy KS. Am J Physiol Gastrointest Liver Physiol. 2013 Aug 15;305(4):G314-24.
ผลงานหนังสือ/ตำราวิชาการ (อยู่ระหว่างการปรับปรุง)
ประวัติการฝึกอบรม/นำเสนอผลงานวิจัย (11 ครั้ง)
1.Signaling by Protease-Activated Receptors PAR1 and PAR2 in Smooth Muscle Reflects Differential Activation of G Proteins: Gq, Gi, and G12 by PAR1 and Gq, Gi, and G13 by PAR2. Wimolpak Sriwai, Jiean Huang, Karnam S. Murhty. *Oral Presentation, May 24th, 2006; DDW 2006, Los Angeles, CA
วันที่ : May 24th, 2006
สถาบันที่จัดอบรม :Los Angeles, CA
2.Feedback Inhibition of RhoA by G12-Coupled PAR1 Receptors in Smooth Muscle Is Mediated Via Inhibitory Phosphorylation of G12 by PKC. Wimolpak Sriwai, Wenhui Hu, Karnam S. Murhty. * Poster Presentation, May 21st, 2006; DDW 2006, Los Angeles, CA * Selected as DDW Poster of Distinction
วันที่ : May 21st, 2006
สถาบันที่จัดอบรม :Los Angeles, CA
3.A Novel Mechanism for Inhibition of RhoA by G13-Coupled PAR2 Receptors in Smooth Muscle Involves PAR2-Mediated Activation of NF-κB and Release of the Catalytic Subunit of PKA from Its Scaffolding Protein IκBα. Wimolpak Sriwai, Sunila Mahavadi, Karnam S. Murhty. Poster Presentation, May 23rd, 2006; DDW 2006, Los Angeles, CA
วันที่ : May 23rd, 2006
สถาบันที่จัดอบรม :Los Angeles, CA
4.Feedback Stimulation of Gαq Function by Gβγ Subunits: A Novel Mechanism Involving Inhibition of Gαq-RGS4 Association and Gαq-GTPase Activity. Karnam S. Murhty, Sunila Mahavadi, Wimolpak Sriwai. Poster Presentation, May 22nd, 2007; DDW 2007, Washington, DC
วันที่ : May 22nd, 2007
สถาบันที่จัดอบรม :Washington, DC
5.Role of AKAP (A Kinase Anchoring Protein) in Phosphorylation of PLC-β3 and Inhibition of PLC-β3 Activity by cAMP-Dependent Protein Kinase in Smooth Muscle. Karnam S. Murhty, Sunila Mahavadi, Wimolpak Sriwai. Poster Presentation, May 20th, 2007; DDW 2007, Washington, DC
วันที่ : May 20th, 2007
สถาบันที่จัดอบรม :Washington, DC
6.Inhibition of Rho Kinase/MYPT1 Pathway by LPA3 and PAR1 Receptors in Smooth Muscle is Mediated by PKA: A Novel Mechanism Involving Activation of NF-κB and Release of the Catalytic Subunit of PKA from Binding to IκBα. Wimolpak Sriwai, Sunila Mahavadi, Karnam S. Murthy. Abstract Submitted , May 19th – May 25th ; DDW 2007, Washington, DC
วันที่ : May 19th, 2007
สถาบันที่จัดอบรม :Washington, DC
7.Inhibition of Sustained Smooth Muscle Contraction by PKA and PKG is Mediated by Phosphorylation of Gα13 and Inhibition of Gα13-Dependent Activation of RhoA. Wimolpak Sriwai, Sunila Mahavadi, and Karnam S. Murthy, Poster Presentation May 30, 2009, DDW 2009 Chicago, IL
วันที่ : May 30, 2009
สถาบันที่จัดอบรม :Chicago, IL
8.Expression of Myosin Light Chain (MLC) Phosphatase Activator (Telokin) and Inhibitor (CPI-17) Determines the Magnitude of Smooth Muscle Relaxation and Contraction, Respectively, in Different Regions of the Stomach. Sunila Mahavadi, Wimolpak Sriwai, Karnam S. Murthy. May 17-22, 2008, DDW 2008 San Diego, CA
วันที่ : May 17-22, 2008
สถาบันที่จัดอบรม :San Diego, CA
9.Expression of Myosin Light Chain (MLC) Phosphatase Activator (Telokin) and Inhibitor (CPI-17) Determines the Magnitude of Smooth Muscle Relaxation and Contraction, Respectively, in Different Regions of the Stomach. Sunila Mahavadi, Wimolpak Sriwai, Karnam S. Murthy. May 17-22, 2008, DDW 2008 San Diego, CA
วันที่ : May 17-22, 2008
สถาบันที่จัดอบรม :San Diego, CA
10.Expression of Multi-Drug Resistance Protein 5 (MRP5), a cGMP Export Pump in Gastrointestinal Smooth Muscle Wimolpak Sriwai, Karnam S. Murthy. May 17-22, 2008, DDW 2008 San Diego, CA
วันที่ : May 17-22, 2008
สถาบันที่จัดอบรม :San Diego, CA
11.Sustained Contraction of Smooth Muscle By PAR1 Receptors Is Selectively Mediated By RhoA/PKC/Cpi-17 Pathway: Evidence That Co-Activation of the RhoA/Rho Kinase/MYPT1 Pathway Is Suppressed By PKA Released from IκBα Wimolpak Sriwai, Sunila Mahavadi, Fang Li, Wenhui Hu, Karnam S. Murthy. May 17-22, 2008, DDW 2008 San Diego, CA
วันที่ : May 17-22, 2008
สถาบันที่จัดอบรม :San Diego, CA

 

 


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